Shar-pei groznica (Šar-pej groznica,FSF/SHS)

Pišem ovaj tekst samo da bi ljudi uspeli da shvate šta može da se desi sa njihovim nagužvanim ljubimcima i samo zato što sumnjam da Marfi ima ovu naslednu ''bolest''. Nemam nameru nekog da isprepadam, pitali ste šta nije u redu sa Marfijem pa da odgovorim.
Familiar Shar-Pei Fever (FSF)- ne znam kako bih tačno preveo ovo ali trebalo bi da bude neka vrsta upale ili groznice kod shar-peia koja je nasledna i koja izaziva povišenu temperaturu kod ove rase. Klinički znak ove nasledne ''bolesti'' je povišena temperatura ( sve iznad 39C je povišeno) koja može da dostigne i veoma visoke temperature (Marfi je u jednom trenutku imao temperaturu 42C). Ukoliko se ne snižava temperatura traje od 12-36 sati i posle tog vremena jednostavno sama prestane. Još jedan od pratilaca ovoga (a ne mora da bude) je i otečen zglob (Swollen Hock Syndrome) uglavnom je u pitanju zglob na zadnjim nogama ( Marfi je poslednji put imao otečen prednji,a prva dva puta zadnje, jednom levi pa desni) i kada se zglob dotakne jasno se može osetiti da je jako vruć i jako bolan na dodir, pas drži nogu podignutu u vazduhu i deluje kao da je noga povređena. Tada je karakterističan hod kao po jajima i u nekim slučajevima, kada je temperatura baš visoka pas je iskrivljen i savijen u predelu stomaka zbog bolova.(doživeli) Pas odbija hranu i vodu prilikom napada i ne može da legne kako treba od bolova.(isto doživeli)
Prilikom povišene temperature oslobađa se neka vrsta proteina u organizmu (mogao bih da napišem koji je, ali zaista nije bitno), a preterana doza proteina u organizmu napada bubrege i u nekim ređim slučajevima jetru. Amiloidoza je hronično oboljenje koje se karakteriše nagomilavanjem abnormalnog proteina amiloida u tkivima i organima. Prvi, i najčešće stradaju bubrezi i posle toga nema spasa. FSF je veoma slično Mediteranskoj groznici kod ljudi ko je čuo za to ili nije nek potraži na netu neke stvari će biti jasnije. FSF je genetski predisponirano oboljenje i prenosi se na potomstvo. Ne postoji lek za ovu bolest,a po istraživanjima 1/3 pasa ove rase boluje od ove bolesti. Ukoliko pas ima FSF ne znači da će razviti amiloidozu ali veliki procenat obolelih pasa je razvije.
Osnovno i najbitnije je primetiti simptome kod psa (otok na zglobu, promenu raspoloženja i naravno povećanu temperaturu) i tada odmah sniziti temperaturu aspirinom ili nekim drugim lekovima korišćenim u veterinarskoj medicini za te svrhe. Visoka temperatura je štetna za psa kao i za ljude jer može da dovede do pregrejavanja,a i oslobađa se taj čuveni protein.
Ne postoji nikakav test za ovo niti neki drugi način da se utvrdi ''bolest'' ali treba kontrolisati mokraću i krv najmanje jedanput godišnje,a kod pasa kod kojih se sumnja da imaju groznicu ili je ona već utvrđena kontroliše se na svaka 3 meseca. Postoji test mokraće na količine proteina u mokraći i na osnovu toga prepisuje se terapija.
Nema neki poseban razlog zbog čega se groznica javlja, kažu da je načešći uzrok stres, preterana fizička aktivnost, neke druge bolesti koje pas ima. Kod Marfija se 3 puta pojavila groznica, visoka temperatura i to dva puta zato što smo ga ostavili predugo samog kući i jednom zato što smo proveli ceo dan van kuće sa njim. Zato sada izbegavamo stresne situacije, mada još nisam u potpunosti siguran da je to baš to,ali svi simptomi su tu. Poslednji put smo mu injekcijama spuštali temperaturu. Piše da ''bolest'' može da se pojavi u bilo kom periodu života ako se otkrije ranije može se kontrolisati nekim lekovima (ja nikad čuo za to kod nas) ukoliko se ne leči maksimalan životni vek je 6god i jako bolna smrt.
Još veći problem je što naši veterinari nemaju pojma ni za neke osnovne bolesti kod pasa,a o našoj rasi da ne govorim, a o ovome tek što nemaju pojma. Moj vet je vikao kako Marfi ima problem sa nogom dok ga ja nisam naterao da mu izmeri temperaturu (42C poslednji put,preterano visoka),kad sam mu pomenu ovu ''bolest'' gledao me je belo i rekao mi je: kad mu skoči temperatura dovedite ga ja ću mu dati injekciju to je jako osetljiva i čudna rasa. Nemam komentar......

Sad, nisam hteo nikoga da uplašim ovim samo sam hteo da prenesem kako stvari stoje i zašto odbijam da parim Marfija iako ima dobar pedigre i lepe ocene sa izložbi. Ne bih mogao da nosim na duši još nekog psa iz Marfijeve linije koji bi se patio celog života, preterano sam se vezao za ovu rasu. Treba sad da mu uzmem uzorak mokraće da proverimo (opet sve moram sam, ali skupljao sam uzorke i sa gorih mesta na njemu) pa nosim u laboratoriju kod nas na svu sreću za pare bi radili i analize za slona i zmije.

Pozdrav

Ukoliko neko želi da pročita ovo o čemu ja pišem,a barata engleskim solidno evo ga link:

http://www.drjwv.com/article.php?view=0004.php&name=Familial+Shar-Pei+Fever(FSF)

Ovo su neki podaci koje sam pronasla na websitu Shar pei kluba iz Amerike....

Familial Shar-Pei Fever
Familial Shar-Pei Fever (FSF) is a hereditary inflammatory disorder seen in Shar-Pei. It
is inherited as an autosomal recessive condition.
Clinical signs:
Episodic fever is the most important and consistent clinical sign of this disorder. The
temperature commonly is in the 105-107°F range. The fever is generally self-limiting
lasting 12-36 hours. Another common clinical sign often accompanying the fever is
swelling of a joint, usually the hock (tibiotarsal) joint and is known as Swollen Hock
Syndrome (SHS). This painful, hot swelling can also involve the carpus (wrist) and the
lips. Dogs with FSF are sick -- they are reluctant to move and when they do walk they
have a characteristic "walking on eggs" gait. They often are painful in the abdomen and
have a characteristic "roached" back.
Pathogenesis:
What we do know about this disease is as follows:
1. Shar-Pei with FSF have increased levels of the cytokine Interleukin-6 (IL-6). IL-6
is involved with the fever response and and is an integral part of triggering the
production of Acute Phase Reactant Proteins by the liver. IL-6 is also involved in
the Systemic Inflammatory Response Syndrome (SIRS). Dysregulation of IL-6 is
the cause of much of the disease in Shar-Pei with FSF. IL-6 also plays a major
role in the body's stress response and serves to "prime" the immune system.
2. Shar-Pei with FSF are at risk from early death from systemic amyloidosis. About
25% of the FSF dogs will develop renal failure including renal amyloidosis -- a
smaller percentage will develop hepatic amyloidosis. This is usually seen in Shar-
Pei between the ages of 2-5 years of age. They also seem more susceptible to
immune-mediated kidney disease such as membranous glomerulonephritis,
protein-losing glomerulopathies, DIC, thromboembolic phenomena such as
mesenteric, splenic and pulmonary embolism and Streptococcal Toxic Shock
Syndrome (STSS).
3. FSF in Shar-Pei was hypothesized to be an animal model of Familial
Mediterranean Fever (FMF) in humans. Recent work indicates this is not true,
although FSF is very similar to FMF in man.
4. FSF is a heredofamilial disease with a genetic basis. It appears to be inherited as
an autosomal recessive condition.
Laboratory Findings:
Unfortunately there are no blood test, etc. which are specific for FSF. During a fever
episode there will often be an increased white blood cell count, an increase in liver
enzyme levels and other non-specific findings. Work done by Dr. Gary Johnson at the
University of Missouri College of Veterinary Medicine to develop a DNA blood test to
screen for the disease was unsuccessful and the research effort will still continue.
Treatment:
It is very important to monitor the temperature in this condition. Initially, fever can be
treated using aspirin. Usually a regular strength adult aspirin is given every 6 hours for
the first 24 hours and then twice a day for 3-5 day thereafter. In rare cases where aspirin
doesn't work of for extremely high fevers, dipyrone is given. Some patients will require
supportive care with intravenous fluid therapy and in extreme cases emergency treatment
similar to heat stroke treatment. Antibiotics are not normally indicated in this condition.
Colchicine:
Colchicine is a drug that has been in use in people with FMF to prevent amyloidosis. It is
currently being recommended in Shar-Pei with FSF for the same purpose. No studies
have been completed to determine if it is useful for this purpose in the Shar-Pei or not.
The clinical impression is that it does help. Those dogs on colchicine seem to have fewer
FSF episodes and less severe signs while on the drug. Side-effects appear to be minimal
at this time and are primarily gastrointestinal such as vomiting, diarrhea, anorexia
(decreased appetite), etc.
Prevention:
Shar-Pei with FSF only show symptoms sporadically. It would appear that there are
"triggers" involved in initiation of the FSF episodes. One of the major triggers appears to
be stress. This may be a dog training class, a dog show, another illness, a dog in heat,
excessive exercise, etc. If the owner can recognize these triggers and take steps to avoid
them the number of FSF episodes can often be reduced. Diet does not appear to be
helpful in prevention of FSF or kidney disease. Surely diet has a role in the management
of the kidney disease once clinical signs are apparent. Low dose aspirin therapy may be
useful in decreasing the incidence of FSF and its severity as well. Aspirin may also be
useful as an adjunct therapy in the prevention of thromboembolism.
Monitoring:
Monitoring for the complications which often accompany FSF is one of the major goals
of the owner of an FSF dog. The primary and most consistent sequela to FSF is kidney
failure either due to immune-mediated kidney disease or renal amyloidosis. I currently
recommend monitoring a urinalysis every 3 months. The sample should be collected first
thing in the morning after the water has been taken up overnight. I primarily look at the
urine specific gravity which is a measure of the concentration of the urine and the protein
levers in the urine. When the kidneys begin to fail the initial indication is a loss in the
ability to produce a concentrated urine. This occurs before there are blood changed
related to kidney failure. Increased water consumption, increased urination are the
clinical signs associated with the loss of concentrating ability, but these signs are often
not recognized. I also thing it is wise to do a blood panel every 6-12 months and certainly
do one in the urinalysis is abnormal. Weighing your dog periodically is very important.
We often don't recognize a significant weight loss because it is very subtle over a longer
period of time. Water consumption and appetite are other important indicators to watch.
Complications of FSF:
We have already discussed the kidney complications in this condition. Other
Complications which have been documented include thromboembolism (mesenteric,
splenic, pulmonary), DIC (disseminated intravascular coagulation), SIRS (systemic
inflammatory response syndrome), MODS (multiple organ dysfunction syndrome), STSS
(streptococcal toxic shock syndrome), hypertension associated with renal failure. Many
of the deaths following an acute FSF episode are due to these complications. No FSF
episode should be treated lightly!
Diagnosis:
There is no specific diagnostic test for FSF at this time. Diagnosis is based on the clinical
sign of episodic fever in a Shar-Pei. I think every Shar-Pei that dies should be autopsied
to determine the cause of death, but this is even more critical in cases involving FSF.
Renal amyloidosis can only be diagnosed based on kidney biopsy and staining with
Congo Red stain. This stain is specific for the presence of amyloid. Amyloid has been
found in other tissues in Shar-Pei as well so special staining should be requested on all
tissues submitted for histopathology. Many dogs with FSF will not have amyloid in the
tissues at the time the tissues were harvested -- this means the absence of amyloid in a
biopsy specimen does not mean that dog will not or would not have gone on to develop
amyloidosis at a later time. To further confuse the issue, not all Shar-Pei with
amyloidosis have shown signs of FSF.
Future:
Research is currently underway at the University of Missouri College of Veterinary
Medicine by Dr. Gary Johnson to develop a DNA blood test. The gene for human FMF
was sequenced in the Fall of 1997 and with that information Dr. Johnson had hoped to
sequence the FSF gene. That information was applied by Dr. Gary Johnson to FSF in a
research project founded by the CSPCA Charitable Trust. That project did determine that
the mutations causing FMF in man do not exist in FSF in the Shar-Pei, hence they are
two distinct, although similar diseases. There are other hereditary inflammatory fever
disorders in man and Dr. Kastner ant the National Institutes of Health are looking at the
disorder with information supplied by Dr. Tintle. Familial Hibernian Fever in man has
also been ruled out as the cause of FSF by Dr. Johnson with information supplied by
NIH. Work will continue to find the genetic mutation(s) responsible for FSF in Shar-Pei.
As of this writing the mutation responsible for FSF has not been found. If a test can be
developed, a screening program can be established to screen breeding stock and
determine normal individuals, carriers and affected dogs. With this information Shar-Pei
breeders can gradually eliminate this genetic disease from the breed. One of the major
obstacles to research revolves around the unpredictable phenotype of FSF. There is no
consistent age range when clinical signs develop, the clinical signs can be variable, some
dogs develop amyloidosis, some don't, etc. This makes it very difficult to use genetic
selection methods which are based on phenotype.
Recommendations:
All Shar-Pei with FSF should be on colchicine and be regularly monitored via urine
samples and blood work for development of complications. Dogs with FSF should not be
used in breeding programs and should be neutered. Dogs with a family history of FSF
should be on colchicine and monitored. Dogs with FSF should be maintained as stressfree
as possible.

Način nasleđivanja šar-pej groznice (FSF/A) prilikom parenja direktno pogođenih groznicom,prenosilaca gena i čistih jedinki:

Parenjem:

-2 čiste jednike:

100% kučića je čisto od groznice.
Ova kombinacija proizvodi 0% pogođenih i 0% prenosilaca.


-1 prenosilac i 1 čista jedinka:

50% čistih jedinki.
50% prenosilaca.
Ova kombinacija proizvodi 0% direktno pogođenih,ali je pola legla prenosilaca.


-1 pogođena jedinka i 1 čista jedinka:

Oko 50% čistih jedinki.
Oko 50% prenosilaca.
Ova kombinacija proizvodi 0% pogođenih,ali oko 50% legla su prenosioci.

-2 jedinke koje su prenosioci parene:

Oko 50% prenosilaca.
oko 25% onih koji su direktno pogođeni.
oko 25% čistih jedinki.
Ova kombinacija proizvodi oko 50% prenosilaca i oko 25% direktno pogođenih.

-1 pogođen i 1 prenosilac:

oko 50% prenosilaca.
oko 50% direktno pogođenih.
Ova kombinacija ne proizvodi čiste jedinke.


-2 pogođena parena:

100% pogođenih.
Ova kombinacija ne proizvodi čiste jedinke.

Izvanredne vesti!!!!

Citat :

DNA Testing for FSF/A
Some Chinese Shar-Pei dogs have a genetic disorder called Familial Shar-Pei Fever (FSF) which is characterized by episodes of unprovoked fever and/or inflammation and sometimes kidney failure and amyloidosis. The disease occurs frequently in the breed and there is a strong need for a genetic test to improve breeding strategies.

We have identified a candidate mutation that significantly correlates with the disease and have developed a test, which we would like to validate on a larger sample number before releasing it for common use. For that purpose we need samples from as many Shar-Pei dogs as possible, to connect the status of the mutation with their medical history. Please help us fight this disease by sending a blood sample to our research group to help validate the test. Thanks!

Click here to download of Health Questionnaire and Release to accompany blood samples to the Broad Institute of Harvard-MIT for research into the genetic assessment of mutation/s associated with risk for for the autoinflammatory conditions Shar-Pei Fever & Amyloidosis. See details in the Questionnaire about collection and shipment. There is no cost to owner for testing of these preliminary samples beyond any collection and shipping fees. Results will be released after sufficient samples are received and data analyzed.

Please complete downloaded PDF forms and send along with 5 ml of EDTA whole blood and serum from 5 ml of centrifuged whole blood on ice, overnight express, to:

Dog Genome Project - Shar-Pei
Broad Institute of MIT and Harvard
7 Cambridge Center
Cambridge MA 02142

For further info, contact Linda Tintle DVM at wvc@warwick.net.

Samples can be drawn at the CSPCA 2010 National Specialty the CLONETN booth Monday through Friday from 8am - 5 pm. Owners will need to stop by the booth to pick up paperwork and make an appointment. Approximately 10 mls (2 Vials) will need to be drawn on each Shar Pei. (Thank you Terry Faulkner!)

izvor: http://www.wvc.vetsuite.com/Templates/ContentPages/More_Info/ClinicContentPage.aspx?guid=96c77dba-9a72-4402-8d7e-fe2150621058

Da pojasnim šta ovde piše: Razvijen je test za utvrđivanje genetske mutacije koja je odgovorna za autoinflamaciju u organizmu shar-peia. Nepoznati napadi temperature, otkazivanje bubrega i amiloidoza kod shar-peia, za sve je odgovorna mutacija i ova gadna NASLEDNA bolest. U svetu je ova bolest postala veoma česta, a bogami i kod nas jer postoji izuzetno mnogo slučajeva pasa koji su uginuli izuzetno mladi pod nepoznatim okolnostima većinom pod pretpostavkom da nešto nije u redu sa bubrezima. Kao što lepo piše u tekstu test je napravljen da bi se pomoglo rasi i da bi se pomoglo odgajivačima da prave strategije parenja. Za početak se rade preliminarna testiranja na većem uzorku pasa i ukoliko se test pokaže kao validan biće pušten na korišćenje.
Od ovog testa će najviše koristi imati sami psi kao i savesni odgajivači koji brinu o onome što izlazi iz njihove odgajivačnice, kao i budući vlasnici koji će moći da izbegnu patnje i gledanje psa kako se savija i na kraju umire u neopisivim bolovima.
Izuzetno mi je drago što je ovako nešto konačno postalo moguće i nadam se da će sve biti u najboljem redu i da će test ugledati svtlost dana.

Linda Tintle DVM ::

We are working on designating European collection sites for receiving samples. I will get that info out soon. The international response has been very strong and positive.

We would like samples from ALL Shar-Pei with good medical records whether they have experienced fever or not. Healthy Shar-Pei will provide us with clues as to why they reach old age with and without various mutations. And we do want the dogs that have fevered or are showing signs of kidney or liver disease as well.

Thank you all for your support of this project. It has been a long painful journey but I think we can improve the health of our beloved dogs and the breed in general with this knowledge.

I have been working on FSF/A since Dr. Steve DiBartola published the first paper on the disorder in August of 1990. I never thought it would take 20 yrs and was beginning to think I would go to my grave without knowing "why". We finally have light at the end of the tunnel.

Prevod:
Radi se na tome da se omogući sakupljanje uzoraka i širom Evrope. Ubrzo će biti postavljene i informacije o tome. Međunarodni odgovor na sve ovo je veoma jak i pozitivan.
Želeli bismo uzorke svih shar-peieva bilo da su doživeli groznicu ili ne. Zdravi shar-peievi će nam dati uvid u to kako su doživeli zrele godine sa ili bez mutacija. I takođe želimo uzorke pasa koji imaju napade ili pokazuju znakove bolesti bubrega i jetre.
Hvala svima na podršci u vezi sa ovim projektom. Bio je to dug i naporan put, ali mislim da možemo popraviti zdravlje svojih voljenih pasa kao i rase generalno ovim znanjem.
Radim na ovome (FSF/A) još od kada je Dr Steve DiBitola objavio prvi članak o poremećaju u avgustu 1990. Nikada nisam pomislila da će biti potrebno 20 godina i mislila sam da neću doživeti da saznam zašto. Konačno imamo svetlo na kraju tunela.

Linda Tintle DVM ::

We would like as many samples as we can get. The young may help us by allowing us to follow their health over the course of their lives. We can then improve how well the test predicts future health and disease and fine tune it by adjusting for variables. ~ Linda

prevod: Voleli bismo što više uzoraka. Mladi nam mogu pomoći tako što ćemo imati uvid u njihovo zdravlje tokom njihovog života. Time možemo poboljšati način na koji test predviđa buduće zdravlje i bolesti i tada podesiti varijable.



Naravno sve nove informacije koje saznam ću odmah preneti ovde.

Linda Tintle DVM ::

We need to validate the genetic test based on a large pool of dogs but what I think we all want from the test is some basis for guiding treatment, prognosis and breeding decisions for our Shar-Pei. Based on preliminary results, I am hopeful that we will gain information to guide care and therapeutics for our dogs now, shed light on prognosis for the future and/or relative risk for that individual and help breeders plan a path away from this badness. ~ Linda

prevod: Treba da potvrdimo genetski test na osnovu velikog broja pasa, ali ono što svi želimo od ovog testa su neka osnove koje će nas voditi prilikom lečenja, prognoza i odluka o parenju naših shar-peieva. Na osnovu preliminarnih rezultata, nadam se da ćemo sakupiti informacije da bismo vodili brigu o svojim psima, da bismo osvetlili prognoze za budućnost i relativan rizik za pojedine jedinke i pomogli odgajivačima u planiranju parenja van ovog zla.

Izvinite, hteo sam da Vas pitam da li znate nacin lecenja od te groznice. Mom psu (Bafi) su pored temperature se pojavile otvorene rane na zadnjim nogama iz kojih tece gnoj. Da li znate kako da je lecimo, jer veterinari ne znaju? Antibioticima?

Hmmm. Prvo temperatura je u ovom slucaju vrlo verovatno pokazatelj za ozbiljnu infekciju.
Temperatura kod Pei groznice se javlja bez nekog odredjenog povoda a zive rane na nogama su i te kakav povod za reakciju imunosistema...i pre rana je sigurno bilo razloga za temperaturu jer se rane otvaraju tek kod zapustenih bakterijskih infekcija.
Analiza krvi, bris sa rana i lecenje antibioticima po antibiogramu....hitno!!!!!
Groznica je druga prica i u ovom slicaju i ako je Bafi ima ona je u drugom planu.

Znaci da kazem veterinaru da uzme te sve briseve?

Hvala Vam puno!!!!! Oticicemo sutra kod veterinara ponovo.

Dobar i odgovoran veterinar ce i sam znati sta treba preduzeti, vadjenje krvi i uzorak iscedtka iz rana je jedini pouzdan pokazatelj o kojoj se bakteriji radi.
Menjaj veterinara Ovaj ocigledno nije dovoljno pouzdan.

Za one koji nikada nisu videli napad groznice FSF/SHS
4 videa verujte da izgleda još gore uživo

Prvi snimak: pas ima oteknut zglob i ne može da spusti nogu čak i kad leži, vidi se da se trese od bolova i visoke temperature